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Interleukin and bFGF for Chronic Acne Vulgaris Treatment

by NOFACE News |

Acne is a disease without known cause.

There are many medical researches explaining the formation of acne, but failed to use the same evidence to explain other types of acnes, or simply put, there's been no real evidence for eliminating acne for everyone. Unlike other diseases (yes, acne is a disease) where a specific virus or bacteria is often found, acne can be thought of as a chain reaction, where one condition stimulates others, such as hormonal imbalance--inflamed glands --- bacteria clusters --- clogged pores --- cysts ---more clogged pores ---more bacteria---more cysts ----- and then repeats. 

acne no face skincare treatment


Research shows that acne can be inhibited 

If there's no known cause, then how do we eliminate the cause ? The answer is we don't need to know the cause to treat the disease, same way we don't have any medication to kill the cold virus, but paracetamols are effective in inhibiting certain proteins in our amino acids in order to make our body react in a different way to reduce the symptoms until the virus is eliminated naturally. With the extensive researches on Acne vulgaris for the past decades, what we now know is that Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the famous Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study (SICS), this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.


Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique.


The median of serum levels of IL-1β, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1Ra and IL-6 between the exposed subgroups.


They found a positive association between serum levels of pro-inflammatory cytokines (IL-1β, IL-8, IL-12 and RANTES) and acne among SM-exposed population.


What does this mean?

The above is only one of the many researches showing a definitive link between interleukin IL-1Ra and the inflammatory acne conditions, suggesting that people with pro-inflammatory cytokines IL-1β, IL-8, IL-12 and RANTES are living with acne vulgaris, and because IL-1Ra is a natural antagonist for the pro-inflammatory cytokines, it inhibits the acne inflammation. 


How do we get IL-1Ra?

If you go to a medical clinic, the doctor may suggest using your own blood to extract the amount of IL-1Ra to boost the skin immune system for the acne treatment. However, the results would only last for during the treatment period, as our blood plasma finally return to the normal levels, the acnes tend to come back. To keep such costly treatments going for life ($500-$1500 per treatment, every 3-4 weeks) may not be a viable solution for most people, and using autologous IL-1Ra is only limiting to this only protein factor. PHYTOGEN© L3-L7 factors provide just the right solutions for patients with acne vulgaris. L3-L4 provide sufficient IL-1Ra to inhibit acne vulgaris, while L5 inhibits bacteria growth, and L6 restores normal skin cells to clear pores and reduce pigmentation and scarring, and then L7 regulates the skin's hormonal behaviors to ultimately control breakout. 


Is IL-1Ra enough?

Researches have shown IL-1Ra's efficacy in inhibiting acne growth through inhibiting inflammation, but reducing inflammation alone may not be enough to eliminate acne vulgaris. Chronic acne inflammation cause the skin stratum corneum to be thin and lack of its original defensive functions against pollutants and the UV, and while the stratum corneum is fragile, acne tends to come back soon after being suppressed. Therefore it is important to repair the skin's stratum corneum through other factors such as bFGF, which has shown tremendously positive results on patients with even high degrees of burn injuries, to repair the burned skin and assist cell growth to reduce scars. bFGF is rich in PHYTOGEN© L6, and is often recommended by dermatologists for patients with scars and acne. 

phytogen acne treatment

PHYTOGEN© L3-L7 Target factors contain high concentrate IL-1Ra, bFGF, plant essence, bacteria inhibiting factors and hormonal regulating factors. 



Get the PHYTOGEN© target factors today to eliminate acne conditions on your face. Try the whole package here  or get selective individual factors here 



Not sure? ask one of our consultants to help you with your skin needs, we will get back to you within a few business hours.